A brief of one of the projects I recently worked.
Cancer stem cells are the small population of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity; exhibiting the characteristics of both stem cells and cancer cells. The functional and the histopathological distribution of CSCs in different grades of astrocytoma with response to malignancy have not been yet, investigated with specific biomarkers. Therefore, the study has been designed to determine the functional contribution of various CSCs, MGMT methylation status and drug response (TMZ) in the presence of MGMT inhibitors on CSCs; to make an understanding, of functional properties of CSCs, the key to future cancer research. The objectives of study have been the prognostic/predictive value of various cancer stem cell markers in different grades of astrocytoma and to evaluate in different grades of glioma cells, the effect of different MGMT inhibitors for chemoresistant glioma stem cells and temozolomide sensitizing.
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Mohania, R. Acharya, S.K. Kalra, K. Jain, D. Tripathi, S. Chandel, S. Mohania, K. Choudhury, S. Jain, S. Bhalla. Clinical correlation of cancer stem cells in low and high-grade glioma of North Indian population. Ann Oncol (2016) 27 (suppl_6): 41P. DOI:https://doi.org/10.1093/annonc/mdw367.19